Prevention Strategies for Monkeypox, including Vaccinating People at Risk via Sexual Exposure, for U.S. Travelers Visiting Countries with Clade I Monkeypox Outbreaks

Recommendations for Travelers

When traveling to a country with ongoing human-to-human clade I MPXV transmission:

• Learn more about which activities may increase your risk of exposure when you travel to a country where clade I MPXV is spreading.
• No matter what your plans are when you visit, if you’re traveling to a country that has an ongoing clade I MPXV outbreak, protect yourself and others from monkeypox, including by:
  • Avoiding close contact with people who are sick with signs and symptoms of monkeypox, including skin or genital lesions.
  • Avoiding contact with contaminated materials used by people who are sick, such as clothing, bedding, toothbrushes, sex toys, or materials used in healthcare settings.
• Talk to your provider about getting vaccinated with two doses of JYNNEOS if:
  • You are traveling to a country where clade I MPXV is spreading between people, AND
  • You anticipate experiencing any of the following:
    1. Sex with a new partner
    2. Sex at a commercial sex venue, such as a sex club or bathhouse
    3. Sex in exchange for money, goods, drugs, or other trade
    4. Sex in association with a large public event, such as a rave, party, or festival
• Get your first monkeypox vaccine at least 6 weeks before traveling, if possible. After completing your first and second vaccine doses, which are given 4 weeks apart, it takes about 2 more weeks to get the best protection against monkeypox.
• Get two doses of JYNNEOS if you are eligible to get monkeypox vaccine because of the clade IIb outbreak that began in 2022 and you’ve never had monkeypox before.
• Know that getting two doses of JYNNEOS is expected to protect you from orthopoxviruses including both monkeypox clades. If you were already vaccinated with two doses, or if you previously recovered from monkeypox, you do not need any monkeypox vaccine doses now.
• Take steps to protect yourself and others from monkeypox even if you are fully vaccinated or have had monkeypox before.

Prevention Strategies for Monkeypox